Abstract
Is oral lichen planus (OLP) by nature a premalignant condition? Few questions in clinical practice have generated more controversy or passionate debate than this one has in recent years. Based on previously published case reports of OLP's progression to squamous cell carcinoma, some clinicians and pathologists are convinced that it is inherently precancerous. 1 Pindborg JJ Reichart PA Smith CJ et al. WHO International Histological Classification of Tumors: Histological Typing of Cancer and Precancer of the Oral Mucosa. Springer, Berlin, Germany1997 Crossref Google Scholar , 2 Silverman S Gorsky M Lozada-Nur F A prospective follow-up study of 570 patients with oral lichen planus: Persistence, remission and malignant association. Oral Surg Oral Med Oral Pathol. 1985; 60: 30 Abstract Full Text PDF PubMed Scopus (280) Google Scholar , 3 Holmstrup P Thorn JJ Rindum J et al. Malignant development of lichen planus-affected oral mucosa. J Oral Pathol. 1988; 17: 219 Crossref PubMed Scopus (181) Google Scholar , 4 Holsmtrup P The controversy of a premalignant potential of oral lichen planus is over. Oral Surg Oral Med Oral Pathol. 1992; 73: 704 Abstract Full Text PDF PubMed Scopus (69) Google Scholar However, others are not persuaded that this is so. 5 Krutchkoff DJ Eisenberg E Lichenoid dysplasia: A distinct histopathologic entity. Oral Surg Oral Med Oral Pathol. 1985; 30: 308 Abstract Full Text PDF Scopus (151) Google Scholar , 6 Lovas JGL Harsanyi BB El Geneidy AK Oral lichenoid dysplasia: A clinicopathological analysis. Oral Surg Oral Med Oral Pathol. 1989; 68: 57 Abstract Full Text PDF PubMed Scopus (28) Google Scholar , 7 Eisenberg E Krutchkoff DJ Controversies in oral pathology: Lichenoid lesions of oral mucosa. Diagnostic criteria and their importance in the alleged relationship to oral cancer. Oral Surg Oral Med Oral Pathol. 1992; 73: 699 Abstract Full Text PDF PubMed Scopus (110) Google Scholar , 8 Allen CM Is oral lichen planus really premalignant? (Editorial). Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 85: 347 Abstract Full Text PDF PubMed Scopus (12) Google Scholar
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