Abstract
Oral Cobalamin (Vitamin B12) Therapy: From Empiricism and Personal Experience to Evidence Based Medicine and Perspective of Recommendations and Guideline
Highlights
Oral Cobalamin (Vitamin B12) Therapy: From Empiricism and Personal Experience to Evidence Based Medicine and Perspective of Recommendations and Guideline
Cobalamin is absorbed by intrinsic factor-independent passive diffusion and daily high-dose oral vitamin B12 can cure cobalamin deficiency, and may induce and maintain remission in patients with megaloblastic anemia [4]
Kuzminski et al [8] in a prospective randomized trial including 38 patients, reported improvement of hematological parameters and vitamin B12 levels, after 4 months of oral cyanocobalamin therapy using a higher dose of cobalamin (i.e. 2000 μg per day)
Summary
Oral Cobalamin (Vitamin B12) Therapy: From Empiricism and Personal Experience to Evidence Based Medicine and Perspective of Recommendations and Guideline. Kuzminski et al [8] in a prospective randomized trial including 38 patients, reported improvement of hematological parameters and vitamin B12 levels (mean value: 907 pg/mL), after 4 months of oral cyanocobalamin therapy using a higher dose of cobalamin (i.e. 2000 μg per day). Bolaman et al [9] in a prospective randomized trial of 60 patients, reported significant improvement of hematological parameters and vitamin B12 levels (mean improvement: +140.9 pg/mL), after 3 months of daily 1000μg of oral cyanocobalamin therapy
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