Oral bioavailability of vancomycin solid-state emulsions

Abstract

Vancomycin was incorporated within water-in-oil-in-water (w/o/w) emulsions prepared from solid-state emulsions. Vancomycin, which is not normally orally absorbed, was significantly absorbed, i.e., 30% ± 0.56 (SE) after 36 h in rats ( N = 3). The vancomycin concentration-time profile indicated that sustained release of vancomycin was very reproducible. Vancomycin was detected in serum by fluorescence polarization immunoassay (TDx, Abbott).