Abstract
Twenty Wistar rats were divided into 4 groups; 3 groups were orally administered by different doses of the herbicide atrazine; (27.3, 38.5, and 42.0 mg/kg b.w), while the 4th served as control. Animals were freely accessed to tab water, and basal diet. Metal cages were interval cleaned twice a week. Cages were kept in 15 C degree. Increased concentrations (p ≤ 0.05) of thyroid stimulating hormone (TSH) compared to control were observed through the course of the experiment. Each mole of sprayed atrazine was found to increase TSH and T3 and decrease FT4. Increasing moles of other sprayed herbicides was found to increase T4, while others resulted in increased levels of TSH, stated [9]. The NOAEL was 50 ppm, equal to 3.2 and 3.34 mg/kg bw/day in males and females, respectively [14].
Published Version
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