Abstract

Gold Nanorod Photothermal Therapy (GNR-PTT) is a minimally invasive technique and an alternative to surgery for destroying tumors while sparing normal tissues. Gold Nanorods (GNRs) with strong extinction peaks in the near infra-red (NIR) spectrum is a good candidate to convert light into thermal energy to destroy tumors. Opto-acoustic imaging (OAI) is a non-invasive method that detects time-resolved acoustic waves created by short pulses of NIR in tissue. It leads to a pressure rise in the irradiated volume. The question of whether OAI is a suitable candidate for temperature monitoring of GNR-PTT in the NIR spectrum was examined. In this thesis, for the first time, GNRs in a gel phantom was used to monitor the temperature during PTT with different laser powers and GNR concentrations. The imaging was performed by a commercial device IMAGIO, Seno, TX. The results show changes of the OA signal follow to temperature changes. The concentration of GNR and the power have a significant role in producing good results.

Highlights

  • IntroductionCancer is a term used for a group of diseases in which abnormal cells divide without control and are able to invade the surrounding and distant healthy tissues

  • The objective of this research is to explore the potential of using optoacoustic imaging for monitoring the temperature variation during a photo thermal procedure

  • Eighteen sets of experiments were carried out using four series of different dilutions of Gold Nanorods (GNRs) exposed to four different powers for each set of dilution, as described in the methods section

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Summary

Introduction

Cancer is a term used for a group of diseases in which abnormal cells divide without control and are able to invade the surrounding and distant healthy tissues. Cancer cells can spread from its origin to other parts of the body area through the blood and lymph systems. This spread, called metastasis can result in death [1]. Chemotherapy, radiation therapy, immunotherapy, hormone therapy and removal or destruction of the tumor by surgery or ablation, or a combination of these approaches are typical cancer treatments [2, 3]. The most direct therapeutic intervention for cancer is surgery. Removing all cancerous cells is the goal of cancer surgery. Choosing surgery depends on factors such as type, size, and location of the tumor. Cancer surgery is not suitable for the treatment of smaller and poorly visible tumors that are deeply embedded in crucial organs

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