Abstract
Micronutrients in rapeseed exert a potential benefit to hepatoprotection, but most of them are lost during the conventional refining processing. Thus some processing technologies have been optimized to improve micronutrient retention in oil. The aim of this study is to assess whether optimized rapeseed oils (OROs) have positive effects on hepatic lipid accumulation and oxidative stress induced by a high-fat diet. Methods: Rats received experiment diets containing 20% fat and refined rapeseed oil or OROs obtained with various processing technologies as lipid source. After 10 weeks of treatment, liver was assayed for lipid accumulation and oxidative stress. Results: All OROs reduced hepatic triglyceride contents. Microwave pretreatment-cold pressing oil (MPCPO) which had the highest micronutrients contents also reduced hepatic cholesterol level. MPCPO significantly decreased hepatic sterol regulatory element-binding transcription factor 1 (SREBP1) but increased peroxisome proliferator activated receptor α (PPARα) expressions, and as a result, MPCPO significantly suppressed acetyl CoA carboxylase and induced carnitine palmitoyl transferase-1 and acyl CoA oxidase expression. Hepatic catalase (CAT) and glutathione peroxidase (GPx) activities as well as reduced glutathione (GSH) contents remarkably increased and lipid peroxidation levels decreased in parallel with the increase of micronutrients. Conclusion: OROs had the ability to reduce excessive hepatic fat accumulation and oxidative stress, which indicated that OROs might contribute to ameliorating nonalcoholic fatty liver induced by high-fat diet.
Highlights
Concurrent with rising obesity prevalence, nonalcoholic fatty liver disease (NAFLD) scalebox has emerged as the most frequent chronic liver disease worldwide
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Significant steatosis in liver was detected when challenged with refined rapeseed oil (RRO) in the present study, which suggested that RRO resulted in the pronounced fat accumulation
Summary
Concurrent with rising obesity prevalence, nonalcoholic fatty liver disease (NAFLD) scalebox has emerged as the most frequent chronic liver disease worldwide. High-fat intake is the most common single cause for NAFLD [3] since long-term consumption of this type of diet promotes obesity and the development of the metabolic syndrome which are highly associated with NAFLD [4] This disease represents a wide spectrum of diseases ranging from simple steatosis to nonalcoholic steato hepatitis (NASH) to advanced fibrosis and cirrhosis. Phenolics are able to improve hepatic lipid accumulation caused by high-fat diet [8] but phytosterols effectively decrease hepatic cholesterol level by inhibiting cholesterol absorption [9] All these beneficial effects make these bioactive components a very important contribution to the recovery from or prevention of liver damage. The present study was designed to investigate whether the various endogenous micronutrient-enriched optimized rapeseed oils (OROs) are capable of decreasing hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
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