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Abstract
Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of these micronutrients are removed by the traditional refining process. The purpose of the present study was to determine whether rapeseed oil fortified with these micronutrients can decrease hepatic lipid accumulation and oxidative stress induced by high-fat diet. Sprague–Dawley rats received rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified RRO with low, middle and high quantities of these micronutrients for 10 weeks. Intake of RRO caused a remarkable hepatic steatosis. Micronutrients supplementation was effective in reducing steatosis as well as total triglyceride and total cholesterol contents in liver. These micronutrients also significantly increased hepatic antioxidant defense capacities, as evaluated by the significant elevation in the activities of SOD and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. These findings suggest that rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent fatty livers such as nonalcoholic fatty liver disease by ameliorating hepatic lipid accumulation and oxidative stress.
Highlights
The typical diet in modern industrialized societies is high-fat content
In our previous report [9], we have demonstrated that rapeseed oil fortified with micronutrients exerts a cardiovascular protective effect
The purpose of the present study was to determine whether this kind of fortified refined rapeseed oil is able to decrease hepatic lipid accumulation and oxidative stress in rats fed a high-fat diet
Summary
The typical diet in modern industrialized societies is high-fat content. Chronic consumption of this type of diet is considered a major cause of a variety of health problems including obesity, diabetes and cardiovascular disease [1]. Feeding a high-fat diet for long periods of time can have adverse effects on liver and result in occurrence of nonalcoholic fatty liver disease (NAFLD) which is one of the leading causes of hepatic dysfunction in the modern world and includes a broad spectrum ranging from benign hepatic steatosis to Rapeseed oil is one of the most common edible oils in the world. It possesses an exceptionally low amount of saturated fatty acids and the predominantly of monounsaturated fatty acids as well as a well-balanced ratio between α-linolenic acid and linoleic acid. Replacing dairy fat with rapeseed oil can cause a rapid and clinically relevant improvement in serum lipoprotein profile including lowering of triglycerides in hyperlipidaemic individuals [5]
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