Abstract
BackgroundMicronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies have been developed to produce various endogenous micronutrient-enriched optimized rapeseed oils. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet.MethodsRats received experiment diets containing 20% fat and refined rapeseed oil or optimized rapeseed oils obtained with various processing technologies as lipid source. After 10 weeks of treatment, plasma was assayed for oxidative stress, lipid profiles and imflammation.ResultsMicronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma.ConclusionsThese results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.
Highlights
Cardiovascular disease (CVD) is the leading cause of premature death in most developed and developing countries and it is an increasingly important source of disability and contributes in large part to the escalating costs of health care
After the rats were acclimated for 1 week, animals were randomly divided into four groups of 10 rats each, consisting of refined rapeseed oil (RRO), cold pressing (CP), dehulling-cold pressing (DCP) and microwave pretreatment-cold pressing (MPCP) groups
Compatible highdensity lipoprotein cholesterol (HDL-C) levels in plasma were observed among all groups (p >0.05), animals in MPCP group exhibited marked decline in TC and low density lipoprotein cholesterol (LDL-C) levels as well as the TG(mmol/L)
Summary
Cardiovascular disease (CVD) is the leading cause of premature death in most developed and developing countries and it is an increasingly important source of disability and contributes in large part to the escalating costs of health care. In addition to triacylglycerols, rapeseed contains many healthy bioactive compounds such as phenolic compounds, tocopherols and phytosterols and these endogenous micronutrients have been reported to possess many health benefits or desirable physiological effects in cardiovascular system. The aim of this study is to determine the effects of the various endogenous micronutrient-enriched optimized rapeseed oils on atherosclerosis risk factors in rats fed a high-fat diet. Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet
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