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Abstract
An extensive research work on development of nanostructured TiO2 layers on the surface of titanium based materials for biomedical implants led the authors to the optimization of process parameters of electrochemical anodization in phosphate/fluoride based electrolytes. Based on those parameters, a dedicated optimized electrochemical anodization setup was originally designed and realized. The anodization bath was designed in order to provide a proper circulation of electrolyte and the possibility of distance anode-cathode modification, the DC power supply was designed accordingly to the electrical parameters requested by the nanotubes development, and a dedicated software (Nanosource) was developed for process control and ease and flexibility of process parameters acquisition, storage and processing.
Highlights
Metallic biomedical implants made of pure titanium or titanium alloys, especially Ti6Al4V, are nowadays widely used in dental implantology, cranio-facial surgery and orthopedic surgery
ȖCorresponding author: gabriela.strnad@ing.upm.ro are capable of promoting bone cell function mainly due to: increase surface roughness/energy, the incorporating of fluoride ions, and the ability to mechanically stimulate cells
The DC power supply was designed to the electrical parameters requested by the nanotubes development
Summary
Metallic biomedical implants made of pure titanium or titanium alloys, especially Ti6Al4V, are nowadays widely used in dental implantology, cranio-facial surgery and orthopedic surgery. They present good mechanical properties, but more important, due to the spontaneous formation of a thin oxide layer onto the surface, they are highly resistant to corrosion and biocompatible. Their osseointegration is the clinical goal of any surgical intervention, and today is well acknowledged that the surface modification of implants enhances the osseointegration. TNT are capable of promoting bone cell function mainly due to: increase surface roughness/energy, the incorporating of fluoride ions (in the case of TNT developed in fluoride based solutions), and the ability to mechanically stimulate cells (this means the geometrical fitting between nanotubes opening of 15...100 nm and the diameter of surface proteins, 10 nm, which are absorbed onto the nano modified surface; these proteins are sensed by integrins, the surface receptors of bone cell membrane, and to them bone cells are attaching to)
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