Abstract
Relevance. The processes of osseointegration in the area of dental implant placement are accompanied by the development of reactions associ-ated with inflammation and activation of local immune processes in peri-implant tissues. Vitamin D preparations can have a significant local effect on the cells of the innate immune defense of the periodontal tissues.The aim of this work is to study the effectiveness of local application of vitamin D on the immune status of the peri-implant sulcus in rehabilitation of patients with partial secondary edentulous and chronic periodontitis by the method of dental implantation.Materials and methods.Determination of the content of biomarkers (IL-1RA, MCP-1, VEGF, TGF-β1, sTNFR) in the crevicular fluid before the installation of implants and the peri-implantation furrow fluid was carried out by the method of enzyme-linked immunosorbent assay using commercial kits «Vector Best» reagents after 3 and 6 months after surgery. The assessment of the state of the bone tissue was carried out using the Orthopantomograph tm OP300 apparatus (KAVO Dental, Germany). Vitamin D has been used topically at a therapeutic dosage.Results.Vitamin D, by reducing Th-1 and Th-17 cell proliferation and differentiation, blocks the activity of the immune-inflammatory process that occurs during implant placement.Conclusion. Application of colecalciferol in patients with moderate periodontitis leads to the activation of the production of immunoregulatory cyto-kines by the cellular structures of the peri-implantation furrow and can be used in combination with the traditional protocol in this category of patients.
Published Version
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