Optimization of NdFeB Permanent Magnets Configuration for Spinal Cord Drug Delivery

Abstract

Magnetic drug delivery is an effective method to decrease the side effects of traditional drug delivery methods. To enhance the efficiency of magnetic nanoparticle transport, a precise and cost-effective magnetic system is required. In this research, different arrangements of NdFeB magnets for drug delivery in human spinal cord were presented and then compared. Assummed magnetic nanoparticles are injected into the cerebrospinal fluid (CSF) and focused on the disease site with external magnets. The effects of these magnets on nanoparticles have been investigated. The results show that the arrangement of sharp magnets has a more accurate performance in delivering nanoparticles to the damage site than other arrangements. The designed magnetic system can improve the accuracy of drug delivery in the spinal cord compared to previous methods.