Abstract
Synthesis of valuable flavour and fragrance compounds is one of the intense applications of lipase-catalysed transesterification. This paper demonstrated application of Novozyme 435 to the synthesis of neryl acetate in a solvent free system. Response surface methodology (RSM) complemented by central com-posite design (CCD) was used to evaluate the effect of various process param-eters on reaction conversion. The results showed that 91.6% conversion of nerol with 100% selectivity to neryl acetate was obtained under the conditions of 1:12.6 mole ratio of nerol to ethyl acetate, 2.6% (w/w) Novozyme 435 at 52.7?C for 2 h. From the kinetic study, it was verified that the reaction followed a ternary complex mechanism with inhibition by ethyl acetate. The process was green, clean and useful to the perfume and flavour industries.
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