Abstract
Colorectal cancer is one of the most common oncological diseases, therefore, the study of this problem is an important issue in clinical practice. This problem becomes especially urgent in case of the formation of anemic syndrome in patients, which causes the emergence of a mutual burden syndrome and increases the risks for a patient. The progressive nature of anemia in colorectal cancer is accompanied by secondary metabolic disorders. The material for the study was the blood plasma of 445 patients (228 men and 217 women). Among them, 53 patients (31 women and 22 men) with iron deficiency anemia were examined and included in the first observation group (І) and 392 patients (206 men (52,55 %) and 186 women (47.45 %)) with colorectal cancer whose course of the underlying disease was burdened with anemia in neoplastic disease were included in the second observation group (II). Among the patients in the second (II) observation group, there were 222 individuals (119 men and 103 women) with malignant neoplasms of the colon (ICD-10 code: С.18), 29 individuals (16 men and 13 women) with malignant neoplasms of the rectosigmoid junction (ICD-10 code: C.19), 138 individuals (82 men and 56 women) with malignant neoplasms of the rectum (code ICD-10 C.20) and 3 patients (2 men and 1 woman) with malignant neoplasms of the anus (ICD-10 code: C.21). The age of the examined patients was from 22 to 79 years. It was found that prior to the initiation of treatment in patients with anemia in neoplastic disease, regardless of the course of colorectal cancer, there was a significant increase in the plasma level of free fractions of heparin, histamine and serotonin (p < 0,001); the ratio of histamine: serotonin was also changed in comparison with the values in the control group (p < 0,05), which indicated both an increased release of heparin, histamine and serotonin from the depot, and an impaired inactivation processes of these biologically active substances. It was correctly concluded that in addition to the baseline therapy the administration of arginine glutamate which causes both antihypoxic and membrane-stabilizing action, reliably contributes to the normalization of secondary metabolic disorders of histamine, serotonin and heparin metabolism in anemia in neoplastic disease in patients with colorectal cancer.
Highlights
Anemia is one of the most frequent complications of cancer
It is believed that an essential link in the anemia in neoplastic disease (AND) pathogenesis is the absence of a compensatory increase in the rate of erythrocyte production, as well as a negative effect on the bone marrow (BM) of cytostatic drugs
53 patients (31 women and 22 men) with iron deficiency anemia (IDA) were examined and included in the first observation group (І) and 392 patients (206 men (52,55 %) and 186 women (47.45 %)) with colorectal cancer (CRC) whose course of the underlying disease was burdened with anemia in neoplastic disease (AND) were included in the second observation group (II)
Summary
Anemia is one of the most frequent complications of cancer It occurs both as a result of the onset, development and progression of the tumour process, and cytostatic and/or radiation therapy, which is used to treat cancer, the presence of hemolysis, splenomegaly, hemorrhagic syndrome, hemodilution, ineffective erythropoiesis, impaired regulation of iron metabolism in the patient’s body, the key link of which is considered to be changes in the hepcidin synthesis (Berganaschi, 2017, Vydyborets, 2017, Gordienko, 2018). This type of anemia is called anemia in neoplastic disease (AND), and the nosological form of this anemia is included in the headings of the International Classification of Diseases (ICD) under the code D63.0. The mechanisms of regulation of these processes have not yet been sufficiently studied
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