Abstract

Medical Electrical Impedance Spectroscopy (EIS) is a non-invasive method, known to be able to determine important properties of tissue at the cellular level. However, due to various factors like geometry of electrodes, position of the sample, reproducibility with EIS is still an issue. In this paper we describe a Lab on a chip (LoaC) for in vitro measurement of the EIS of animal tissue. The LoaC consists of a capacitive cell, of rotationally symmetric electrodes; five on either side of the volume holding the test tissue sample in a saline solution. The geometry has been chosen to minimize the uncertainty due to the unknown position of the tissue within the electrode system. A semi-analytical model is developed to analyze the sensitivity of the parallel annulus electrode system to impedance changes within the test volume. Furthermore, constraints on the handling and localization of excised tissue are used to design a practical LoaC to yield the most repeatable EIS measurements.

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