Abstract
The objective of the present study was to develop filler-binder co-processed excipient (CPE) from MCC PH 102 and Povidone® K 30 combination. The mixture was varied and co-processed by spray drying technique. Optimum proportion was determined by testing the flow ability and compressibility expressed in Tapping Index (T.I) and hardness, respectively. The test result indicates that the flow ability was fluctuating in different CPE proportions, while compressibility improved with the increase in proportion of Povidone ® K 30. Optimum proportion was reached at 71 % MCC PH 102 and 29 % Povidone ® K 30, with the values of T.I and hardness of 16,22 ± 0,39 % and 7,61 ± 0,12 kg, respectively. Optimum CPE generates tablets of paracetamol model drug that meet the USP requirements of tablet dosage, which include hardness, friability, disintegration time, and dissolution.
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