Abstract
Tablets at present, remain the most preferred oral dosage form because of many advantages they offer to formulators as well as physicians and patients. The objective of this work was to determine the effect of co-processing on the disintegration and drug-release profile of ibuprofen tablets prepared from a co-processed excipient. The co-processed excipient (CE) containing lactose, gelatin and mucin in the ratio 90:9:1 was prepared using co-fusion. The excipient was evaluated for its physicochemical properties and then used to formulate tablets with the addition of a disintegrant by direct compression. The tablets were evaluated for their tablet properties and compared with tablets prepared with cellactose- 80® (CEL) and spray dried lactose® (SDL) and a physical mix (PM) of the co-processed ingredient. Results from evaluation of CE showed that flow rate, angle of repose, Carr’s index and Hausner’s ratio were 5.28 g/sec, 20.30o, 23.75 % and 1.31, respectively. Tablets prepared with CE had friability (0%), crushing strength (5.25) KgF, disintegration time (3 mins) and T50% (2 mins). For CEL, friability (0.4 %), crushing strength (7.25) KgF, disintegration time (1 min) and T50% (2 mins); SDL, friability (1.57 %), crushing strength (7.50) KgF, disintegration time (4 mins) and T50% (2 mins) and PM, friability (2.38 %), crushing strength (5.00) KgF, disintegration time (1 min) and T50% (2 mins). In conclusion, the disintegration time and drug release profile for CE was not superior but compared favorably with CEL, SDL and PM.
Highlights
Drug administration, through the oral route has been very popular for the usage of medicinal agents in managing diseases since it gives room for safety, permits self-medication, ease of ingestion of drug product, etc. and these enhance patient compliance (Quodbach and Kleinebudde, 2016).The large surface area of the gastrointestinal tract which favors drugBio-Research Vol.18 No 1 pp. 1120-1126 (2020)absorption, provides sufficient fluid to facilitate disintegration of the dosage form and dissolution of the drug thereby making the oral route the most appealing route for drug delivery despite the advancements made in the new drug delivery systems (Desai et al, 2016)
The tablet disintegration process is very critical for the immediate release dosage forms and consequent upon that, disintegrants are added to tablets to induce break-up when it comes in contact with the fluid (Sastry et al, 2000)
A disintegrant is described as an inert substance that is added to a solid dosage formulation such as a tablet or capsule to cause their breakup that will lead to the release and dissolution of the active pharmaceutical ingredients (API)
Summary
Through the oral route has been very popular for the usage of medicinal agents in managing diseases since it gives room for safety, permits self-medication, ease of ingestion of drug product, etc. and these enhance patient compliance (Quodbach and Kleinebudde, 2016).The large surface area of the gastrointestinal tract which favors drugBio-Research Vol. No 1 pp. 1120-1126 (2020)absorption, provides sufficient fluid to facilitate disintegration of the dosage form and dissolution of the drug thereby making the oral route the most appealing route for drug delivery despite the advancements made in the new drug delivery systems (Desai et al, 2016). A disintegrant is described as an inert substance that is added to a solid dosage formulation such as a tablet or capsule to cause their breakup that will lead to the release and dissolution of the API. They act by increasing the surface area of the tablet and softening the binding agent through swelling which is often accepted as the key mechanism of tablet disintegration. This on its own, enhances the rate of dissolution in the media (Sharma et al, 2019). A much broader platform for the manipulation of excipient functionality is provided by co-processing or particle engineering of two or more excipients
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