Abstract
Ketoprofen is a NSAID which often used, but has been shown to induce gastrointestinal irritation. The side-effect arises because of the presence of carboxylic acid groups. The carboxylic acid groups can be changed by estherification reaction between ketoprofen and eugenol using an acid catalyst. This study was purposed to find out the effect of mole ratio of ketoprofen : eugenol on the synthesis Ketoprofen Eugenol Ester (KEE). The mole ratio of ketoprofen : eugenol which used in the study were 1:3; 1:4; 1:5; 1:6; 1:7; 1:8. The synthesis was done by heating up ketoprofen, eugenol, and HCl as the catalyst. The results of synthesis were characterized using TLC, FTIR, UV-Vis Spectrophotometer, and HPLC. Then, the data was analyzed statistically using One Way ANOVA (SPSS). The result of sample analysis using TLC showed the Rf value ±0.07. The FTIR analysis indicated that there were peak C=O ester and C-O ester. The highest yield value, absorbance of UV-Vis spectrophotometer and peak area of HPLC were found in the mole ratio 1:6. The One-Way ANOVA statistical analysis indicated that there was a significant difference between the variations of mole ratio which were used.
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