Optimal multimodal multi-echelon vaccine distribution network design for low and medium-income countries with manufacturing infrastructure during healthcare emergencies

Abstract

In the event of routine immunizations for containing disease outbreaks, the Expanded Programme on Immunization (EPI) led Low and Medium-Income Countries (LMICs) follow a four-tier distribution network. Such a network is suitable for LMICs importing vaccines rather than manufacturing and may not be suitable for healthcare emergencies. Recent shift from routine immunizations to pandemic-orientation, calls for large-scale multimodal distribution models. This paper proposes a cold chain network for LMICs with manufacturing hubs during health emergencies, integrating vaccine manufacturers and incorporating multiple transportation modes. The problem is formulated as a Mixed Integer Quadratically Constrained Programming (MIQCP) problem, to minimize ‘Cumulative Transportation Time’ (CTT) with the minimal number of trips. To solve large-scale problems the paper also proposes a novel algorithm that divides certain parts of the network and retains the edges that are likely to give better solutions. The proposed model extends the existing body of the literature by introducing features such as vehicle choice between locations, generalized hierarchical structure, network decomposition, and appropriateness with LMIC networks. We conduct numerical experiments to validate the proposed algorithm using data from India. The results show that the proposed model saves cumulative transportation time along the optimally generated network when compared with the actual vaccine supply network in India during healthcare emergencies. The proposed algorithm is also faster than the formulation giving comparable results while solved in a commercial solver.