Optimal generalized case–cohort sampling design under the additive hazard model

Abstract

ABSTRACTGeneralized case–cohort designs have been proved to be a cost-effective way to enhance effectiveness in large epidemiological cohort. In generalized case–cohort design, we first select a subcohort from the underlying cohort by simple random sampling, and then sample a subset of the failures in the remaining subjects. In this article, we propose the inference procedure for the unknown regression parameters in the additive hazards model and develop an optimal sample size allocations to achieve maximum power at a given budget in generalized case–cohort design. The finite sample performance of the proposed method is evaluated through simulation studies. The proposed method is applied to a real data set from the National Wilm's Tumor Study Group.