Abstract
This paper deals with the optimal design of two interconnected Continuous Stirred Bioreactors in which a single enzymatic reaction occurs. The term “optimal” should be understood here as the minimum of the total volume of the reactors required to perform a given conversion rate, given a quantity of matter to be converted per time unit. The optimal design problem is solved for a wide class of kinetic functions including, in particular, the well known Michaelis-Menten kinetic. The analysis of the optimal configurations is investigated, and it is shown that the concept of “Steady State Equivalent Biological System” (SSEBS) first introduced by Harmand et al., (2003a) for microbial reactions only applies to enzymatic systems which have nonmonotonic kinetics. In addition, a stability analysis of the optimal configurations is performed.
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