Abstract
Objective: To evaluate the clinicopathological characteristics, treatment methods, survival, and prognosis of ovarian clear-cell carcinoma (OCCC). Material and Methods: All patients with OCCC who were treated between January 1998 and October 2012 were retrospectively reviewed. After the exclusion criteria, a total of 39 women were included in the present study. Univariate and multivariate analyses were used to identify the risk factors for overall survival (OS) and progression-free survival (PFS). Results : The majority of the patients were at stage I disease (n=21 [24.3%]). All patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Additionally only pelvic, and pelvic plus para-aortic lymphadenectomy was done in 8 (20.5%) and 19 (48.8%) women, respectively. Optimal cytoreductive surgery was achieved in 26 (66.7%) patients. Recurrences occurred in 11 (28.2%) patients. The median follow-up period was 51 months (range 4 – 132 months). The 5-year PFS and OS rates were 47% and 54%, for all patients. The 5-year OS rates for women with early (stage I and II) and advanced (stage III and IV) stage disease were 56.4% and 38.1%, respectively. Multivariate analysis confirmed optimal cytoreduction as the only independent predictor of OS [Odds ratio (OR) 21.212, 95% confidence interval (CI) 5.259–85.556, (p<0.001)] Conclusion : Optimal cytoreductive surgery is the only independent good prognostic factor for survival in patients with OCCC.
Highlights
Ovarian cancer is the most lethal malignancy of the genital tract [1]
They are generally associated with poor prognosis and distinct clinical features compared to other subtypes of Epithelial ovarian cancer (EOC) [5]
24 (61.5%) patients were categorised as early stage and 15 (38.5 %) patients were categorised as advanced stage
Summary
Ovarian cancer is the most lethal malignancy of the genital tract [1]. Epithelial ovarian cancer (EOC) accounts for 90–95% all ovarian cancer types. Ovarian clear cell carcinoma (OCCC) is a rare subtype of EOC, constituting approximately 5% to 25% of cases [2,3]. These tumors were first described and originally named as ‘mesonephroma ovarii’ due to the patological findings including hobnailed clear-cells with an immature glomerular pattern (Fig 1) [4]. OCCC is more likely to be diagnosed at an earlier stage and occur unilaterally [5,6,7] They are generally associated with poor prognosis and distinct clinical features compared to other subtypes of EOC [5]. An association between endometriosis and OCCC was described and nulliparous women are considered to be at higher risk like women with most subtypes of EOC [6,8,9]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call