Abstract

We apply innovative mathematical tools coming from optimal control theory to improve theoretical and experimental techniques in Magnetic Resonance Imaging (MRI). This approach allows us to explore and to experimentally reach the physical limits of the corresponding spin dynamics in the presence of typical experimental imperfections and limitations. We study in this paper two important goals, namely the optimization of image contrast and the maximization of the signal to noise per unit time. We anticipate that the proposed techniques will find practical applications in medical imaging in a near future to help the medical diagnosis.

Highlights

  • Optimality with respect to a given criterion is vital in many applications, but it presents a complexity that requires a lot of ingenuity to provide a solution

  • Optimal control theory was born in its modern version with the Pontryagin Maximum Principle (PMP) in the late 1950’s

  • Its development was originally inspired by problems of space dynamics, but it is a key tool to study a large spectrum of applications extending from robotics to economics and biology [5, 12, 14, 15, 18, 19, 23, 27, 29]

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Summary

Introduction

Optimality with respect to a given criterion is vital in many applications, but it presents a complexity that requires a lot of ingenuity to provide a solution. The development of theoretical techniques, such as composite and shaped pulses in MRI has so far relied on a relatively small number of concepts and numerical tools that have led to many practical improvements in the last decades [45] These improvements were largely incremental, none of those approaches was able to establish physical limits of the best possible performance in terms of energy deposition, sensitivity, robustness and contrast. The aim of this paper is to present two examples of recent results obtained in this direction both from the geometric and numerical approaches These examples will allow us to describe and discuss the efficiency and the limitations of this method in order to solve applied and concrete issues in MRI.

Optimal control of the signal to noise ratio per unit time
The model system
How to move in the Bloch ball
Conclusion
Methods

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