Optimal Adaptive Designs in Phase III Clinical Trials for Continuous Responses with Covariates

A Biswas,S Mandal

doi:10.1007/978-3-7908-2693-7_6

Optimal Adaptive Designs in Phase III Clinical Trials for Continuous Responses with Covariates

A Biswas, S Mandal

https://doi.org/10.1007/978-3-7908-2693-7_6

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Publication Date: Jan 1, 2004

Citations: 27

Affiliation: Indian Statistical Institute, University of Manitoba

#Optimal Adaptive Design #Adaptive Design + Show 8 more

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Abstract

Some optimal adaptive allocation design was given by (2002) for phase III clinical trials involving two treatments having binary responses, but no covariate. We extend that idea to introduce an optimal adaptive allocation design for two treatments having some continuous responses. Moreover, we allow covariates in our model. Exact and limiting proportion of allocation for the proposed design are numerically evaluated.

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