Abstract

The role of oxygen in skin care is well known for assisting in skin rejuvenation and repair. This work is an unprecedented scientific and clinical effort to understand changes in percent skin oxygen saturation level (StO2) with topical application of a range of oxygen therapeutic skin care products, and in a course of skin breakout, using a newly developed three-wavelength system in a trial involving a total of eight volunteers. This technology is able to provide measurable positive effects on facial StO2 of the recruited volunteers one week after the topical application of oxygen creams with mean (standard deviation, SD) relative change in StO2 of 5.8 (4.6) %. Meanwhile a case study using this system on an individual with untoward skin condition revealed a drastic change in the mapping of StO2 values from the formation of papule to pustule, and to its encrustation. This optical technology could be a significant breakthrough in the dermatology research by redefining pharma-cosmeceutical research design and process in the development of skin care products by evaluating the efficacy of these products in improving skin oxygen level. In the future, this system may have major applications in the translational research of human physiology and pharmacology.

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