Abstract
In this work, we reported an efficient method for eliminating the optical trapping effect on characterization of nanoparticle diffusion parameters by resonance light scattering correlation spectroscopy (RLSCS). The RLSCS represents a new single nanoparticle method and its principle was based on measuring the resonance light scattering fluctuations in a highly focused laser beam due to the Brownian motion of single nanoparticles such as gold nanoparticles (GNPs), which resembled fluorescence correlation spectroscopy (FCS). In RLSCS analysis, the polarizability of nanoparticles are much higher than fluorescent molecules in FCS, and the sizes of them are larger, therefore, the optical trapping force significantly affects the diffusion behaviors of nanoparticles under a highly focused laser beam. In this study, we used the 632.8 nm He—Ne laser as the light source, which was close to the resonance scattering band of GNPs, and chose GNPs (from 20 to 100 nm) as model samples. We theoretically and experimentally ...
Published Version
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