Abstract
Optical imaging of intrinsic signals maps the brain by measuring intrinsic activity-related changes in tissue light reflectance and absorbance. These signals result from changes in local blood volume, hemoglobin oxygenation, and tissue light scattering changes that are coupled to neuronal activity. Because it offers an excellent combination of spatial sampling, spatial resolution, and temporal resolution, it is a versatile brain mapping tool that can be used alone or in combination with other brain mapping techniques to characterize neurovascular physiology, map the brain, and investigate disease in a variety of species, including rodents, primates, and humans.
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