Abstract
A noninvasive optical technique has been developed for imaging in vivo blood flow dynamics and vessel structure with high spatial resolution. The technique is based on optical Doppler tomography, which combines Doppler velocimetry with optical coherence tomography to measure blood flow velocity at discrete spatial locations in turbid biological tissue. Applications of this technique for monitoring changes in blood flow dynamics and vessel structure following pharmacological intervention and photodynamic therapy are demonstrated.
Highlights
Noninvasive techniques for imaging in vivo blood flow are of great value for biomedical research and clinical diagnostics [1] where many diseases have a vascular etiology or involvement
High spatial resolution is possible because light backscattered from the sample recombines with the reference beam and forms interference fringes only when the optical path length difference is within the coherence length of the source light
We describe in this paper the development of an Optical Doppler tomography (ODT) system for noninvasive in vivo imaging of blood flow dynamics and tissue structures with high spatial resolution in the chick chorioallantoic membrane (CAM) and rodent mesentery
Summary
Noninvasive techniques for imaging in vivo blood flow are of great value for biomedical research and clinical diagnostics [1] where many diseases have a vascular etiology or involvement. Using a Michelson interferometer with a low coherence light source, ODT measures the amplitude and frequency of the interference fringe intensity generated between reference and target arms to form structural and velocity images. High spatial resolution is possible because light backscattered from the sample recombines with the reference beam and forms interference fringes only when the optical path length difference is within the coherence length of the source light.
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