Abstract
We present two optical breast atlases for optical mammography, aiming to advance the image reconstruction research by providing a common platform to test advanced image reconstruction algorithms. Each atlas consists of five individual breast models. The first atlas provides breast vasculature surface models, which are derived from human breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data using image segmentation. A finite element-based method is used to deform the breast vasculature models from their natural shapes to generate the second atlas, compressed breast models. Breast compression is typically done in X-ray mammography but also necessary for some optical mammography systems. Technical validation is presented to demonstrate how the atlases can be used to study the image reconstruction algorithms. Optical measurements are generated numerically with compressed breast models and a predefined configuration of light sources and photodetectors. The simulated data is fed into three standard image reconstruction algorithms to reconstruct optical images of the vasculature, which can then be compared with the ground truth to evaluate their performance.
Highlights
Background & SummaryOptical mammography (OM) based on diffuse optical tomography (DOT) is an emerging medical imaging modality for non-invasive, functional imaging of human breast[1]
DOT provides tomographic maps of optical properties, which can be translated to physiological parameters such as blood volume and blood oxygenation
We present much more realistic breast models that are derived from human breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data
Summary
Optical mammography (OM) based on diffuse optical tomography (DOT) is an emerging medical imaging modality for non-invasive, functional imaging of human breast[1]. Researchers have been addressing the existing problems with DOT from two aspects: optical instrumentation and image reconstruction[3]. The major mathematical problem in DOT is to generate maps of optical properties from the measurements. In the case of DOT, the inverse problem is generally ill-posed and much more challenging due to the strong scattering of photons in human tissue. To make the situation even worse, the data is usually acquired with custom-designed instruments rather than commercial products following industrial standards It is questionable if an algorithm optimized for a specific instrument will perform well for other systems. To demonstrate the usefulness of the optical breast atlases, we further provide simulated measurement data obtained from compressed breast models as technical validation. The quality of reconstructed images is assessed by comparing them with the ground truth
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