Optical biosensors based on microfluidic chip

Abstract

Microfluidic chips have the advantages of small sample size, low detection cost, and short detection time. Combined with optical sensors, electrochemical sensors, and microwave sensors, they can be used to construct sensitive, repeatable, and portable detection systems. Optical biosensors are powerful analytical instruments that can measure biomolecular interactions in real-time and unlabeled manner. The combination of affinity and kinetics can be measured through high sensitivity. many optical biosensors have microfluidic control, making them extremely sensitive. Combining the concept of microfluidic technology, this article briefly elucidates the various cutting-edge research fields of microfluidic technology combined with optical biosensors, such as optical detection methods suitable for microfluidic chips, microfluidic biological immunofluorescence detection, the application of microfluidic technology in optical detection methods. It also prospects the future development direction and the challenges as well as strategies for addressing the problems in the development of the new generation of biological microfluidic sensors were proposed.