Abstract
Both bongkrekic acid (BA) and atractyloside (ATR), have been shown to be specific inhibitors of the adenine nucleotide (ANP) translocation in mitochondria [l-3]. This inhibition, however, is obtained by opposite effects of these antibiotics on the ANP carrier: whereas ATR prevents binding of ANP to the carrier sites, BA prevents dissociation of the ANP from the carrier sites [4]. In the present communication two further examples for opposite effects of BA and ATR on mitochondrial functions related to the ANP carrier will be described.
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