Abstract
The spindle is a macromolecular machine assembled from microtubules and motors to accurately segregate the genome at each cell division. How motors together give rise to the mammalian spindle's emergent architecture, mechanics, and function remains poorly understood. The motors dynein and Eg5 are each key to bipolar spindle formation: dynein mediates contractile microtubule minus-end clustering, and Eg5 drives extensile microtubule sliding. Yet when both are inhibited, the spindle can still establish its normal shape.
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