Opportunities of using gene therapy in patient with non-reconstructable critical limb ischemia in proximal reocclusion

Abstract

The aim of the study: to evaluate the effect of complex treatment on "no-option” patients with aortoiliac reocclusion using a plasmid-based with VEGF165 gene therapy in the 3-year follow-up study. Material and methods. In total, 3 patients with Leriche's syndrome in stage III, IV of chronic lower limb ischemia (according to the classification of Fontaine-Pokrovsky) were treated and observed in the 3-year follow-up study. All patients were men, the average age was 58 years. All patients underwent surgical reconstruction of the aortoiliac segment. In the period from 1 to 3 years after the initial intervention, there was a reocclusion of the aortoiliac segment. Based on the results of angiography, these patients were classified as non-reconstructable due to total occlusion of lower extremity arteries. All patients received standard conservative treatment in combination with gene therapy. Endpoints of the study: the survival rate, the limb salvage rate. Results: During 3-year follow-up two patients are alive, one dead due to unrelated with Leriche's syndrome reasons, the limb salvage rate was 100 %.