Abstract
Of two related Macaca species, the rhesus ( M. mulatta), acquires opiate tolerance and dependence more readily than the cynomolgus ( M. fascicularis). In the cynomolgus, μ-opiate receptors were significantly fewer in the caudate nucleus and globus pallidus; δ-sites were fewer in the thalamus. κ-Sites showed no species difference. The levels of [Met 5]enkephalin, substance P and dynorphin B in various brain areas were comparable. On the other hand, receptor-assayed endorphin activity was higher in CSF of cynomolgus than rhesus monkeys.
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