Abstract
Open questions: A rose is a rose is a rose - or not?
Highlights
The first to be afflicted were immunologists and hematologists, but genomicists have succumbed to 'splitter’s disease'
What could this apparent lack of genetic regulation in single cells reflect? Only two major possibilities present themselves
Lander previously commented on this issue when discussing how hematopoietic stem cells maintain their numbers [6]
Summary
The first to be afflicted were immunologists and hematologists, but genomicists have succumbed to 'splitter’s disease'. A snapshot of the cell will show a transcript ratio that does not reflect the time integral of expression that controls the protein level, which is likely to be less spikey.
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