Abstract
and different amniotic fluid parameters are associated with birth weight. Methods: 210 patients with singleton pregnancy and gestational age between 15+0 and 17+6 weeks were included in our study. Fetal biometry with regard to biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC) and femur length (FL) was routinely performed. Placental volume and vascularization were assessed by 3D ultrasound and 3D power Doppler. Placental volume (PV), four placental ratios (PR1 = PV/BPD; PR2 = PV/HC; PR3 = PV/AC, PR4 = PV/FL) and vascularization indices (VI, FI, VFI) were calculated. Visfatin, leptin, endoglin, VEGF and PIGF were measured in the amniotic fluid. Results: While in linear regression analysis both PV, the four placental ratios, VI and VFI had a significant influence on birth weight only FI significantly predicted birth weight below the 10th percentile in logistic regression analysis. Leptin and Visfatin in the amniotic fluid were significantly associated with birth weight in linear regression analysis. The same applied to VEGF and PV/FI. Conclusions: Second trimester placental volume and vascularization parameters correlate with birth weight. Additionally, leptin and visfatin in the amniotic are associated with fetal development. Placental volumetry and vacularization may be early markers for fetal growth anomalies.
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