OP05.09: The development of senses-a concept for future trials

Abstract

Results: From 121 fetuses the median gestational age was at first examination 30 wk and at birth 31 1/7 wk, the median birth weight was 1318g. General movements were normal, suspect and abnormal in 42%, 17% and 41%, respectively. Echogenicity changes of the brain were absent, mildly or moderately abnormal in 28%, 41% and 31%, respectively. The sensitivity of general movements for moderate echogenicity changes (periventricular ≥ IB: brighter than choroid plexus, intraventricular grade II, III filling <, ≥50%, in basal ganglia/thalamus locally increased) per brain area and the three areas together was 0.53–0.85, specificity 0.40–0.44, positive predictive value 0.13–0.35, negative predictive value of general movements was 0.81–0.96. Conclusions: Qualitative abnormal general movements predict moderate echogenicity changes in the brain especially in the periventricular area in fetuses of pregnancies complicated by hypertensive disorders or preterm labour. Normal general movements predict absence of moderate echogenicity changes.