Abstract
Genome sequencing (GS) is a powerful clinical tool used for the comprehensive diagnosis of germline disorders. WGS library prep typically involves mechanical DNA fragmentation, end repair, bead-based library size selection, and adapter ligation, which usually requires a large amount of input genomic DNA. Tagmentation using bead-linked transposome can simplify the library prep process and reduce the DNA input requirement. Here we describe clinical validation of tagmentation-based PCR-free GS as a clinical test for rare germline disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
