Abstract
and were similar among older and younger adults (all p N 0.05). The subscales with the greatest improvement were social function and role function. Although 2MWT improved by 64% and 68% among younger and older patients (p = 0.69), improvements in grip strength and timed chair stands were much smaller (24% and 39% in younger adults, 15% and 18% in older adults, respectively). Patterns of recovery in physical performance were similar among older and younger adults (all p N 0.05). Results were similar when missing data were imputed. Conclusion: Survivors of AML after successful intensive chemotherapy achieve significant improvements in QOL, fatigue, and physical function by one year after diagnosis. The course of recovery is remarkably similar in younger and older AML patients, although significant attrition in older adults is a noteworthy limitation and fatigue improved less in older adults than younger adults. These data suggest that appropriately selected older patients generally recover as well as younger adults following IC for AML.
Published Version
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