Abstract
Obesity has reached epidemic proportions in modern societies with a prevalence of more than 20% of the population and has been recognized as a risk factor for numerous metabolic disorders including type 2 diabetes, cardiometabolic, liver and renal diseases. Onset and disease progression is closely associated with metabolic reconfiguration of white adipose tissue (WAT) in which a constant low-level inflammation in obese WAT may lead to protein and lipid oxidation altering cellular signaling. Oxidized lipids represent a complex class of cellular signaling mediators that are, due to their complexity and wide dynamic range, difficult to analyze. In order to understand the role of oxidized lipids in WAT pathology several lipid extraction and fractionation methods were used on WAT biopsies followed by untargeted LC-QTOF-MS/MS analysis. With the help of in-house developed LPPtiger software ( https://bitbucket.org/SysMedOs/lpptiger ), WAT native lipidome is further used to predict and identify oxidized lipid species formed under pro-inflammatory conditions associated with obesity. Identified oxidized lipids will be further implemented into WAT specific metabolic networks to understand the role of lipid redox mediators in adipose tissue dysfunction.
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