Abstract
In a previous study (Ratty et al., 1990), the discovery of a transgenic mutant mouse that displayed abnormal circling behavior was reported. Mice homozygous for the transgene display this phenotype, whereas heterozygotes are phenotypically normal. In this study, circling mutants displayed excessive lateralized circling behavior and locomotor hyperactivity by Postnatal Days (PND) 14 and 16, respectively. These abnormalities persisted unattenuated through adolescence and adulthood. Disturbances in rearing and grooming were also observed in circling mutants. Surface-righting ability in the mutants was normal, and the age of eye opening was only marginally delayed. However, body weights of the mutants were reduced compared with normal mice from PND 15 to adulthood. Possible relationships between the behaviors that are exhibited by circling mutants and previous neurochemical findings are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
