Abstract
Background: Several factors, including anemia, diabetes, and hypertension, potentially could disturb the cerebral autoregulation mechanism in hemodialysis (HD) patients. This study examined the effect of hemodynamic and rheological changes on mean cerebral blood flow (CBF) velocity (MV) during HD. Methods: Continuous online monitoring of MV and pulsatility index in the middle cerebral artery were performed in 18 HD patients by transcranial Doppler ultrasound during the entire HD period (range, 3 to 4 hours). In addition, blood pressure, hematocrit (Hct), and relative decrease in blood volume were continuously monitored. Blood samples were obtained at the beginning and end of HD to measure hemorheological variables. Results: After HD, Hct increased significantly from 33.6% ± 5.9% to 41.4% ± 5.7% (P < 0.001). Blood and plasma viscosity increased significantly from 3.33 ± 0.77 to 4.36 ± 1.3 mPa.s (P < 0.001) and from 1.35 ± 0.29 to 1.54 ± 0.38 mPa.s (P < 0.001), respectively. The change in MV (ΔMV) was not significantly different from zero and correlated significantly with change in Hct. During HD, mean arterial pressure (MAP) in 15 patients changed within the normal range (group I), whereas 3 patients developed hypotension (group II) and their MAP decreased from 99 ± 5 to 60 ± 8 mm Hg (P < 0.05). In both groups, ΔMV were not significant. Conclusion: Results of this study suggest that CBF does not appear to be diminished significantly during HD. Am J Kidney Dis 40:996-1004. © 2002 by the National Kidney Foundation, Inc.
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