Abstract
The multiplication of vaccinia virus in cultures of monkey kidney cells has been studied. One-step growth curves indicate that the virus particles in eclipse are responsible for replication, that the eclipse period for vaccinia virus lasts 8–10 hours, that the increase of infectious virus is exponential, and that the yield is 300 plaque-forming units per infected cell at 24 hours. Few particles are released by this time. Adsorption of virus to the cell occurs in two stages, only the first of which is susceptible to neutralization by antibody. Following antibody treatment of infected cells, infectious particles which can be recovered from cells after sonic vibration fall into two classes, only one class being susceptible to neutralization by antibody.
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