Abstract
α‐Aminophosphonates (4a-j) were synthesized in one‐pot simultaneous reaction of 4‐bromo‐3‐methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik‐Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.
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