Abstract
Being stressed by, for instance, a chemical trigger can result in an organism increasing resistance to other chemicals or even to physical and biological triggers. This phenomenon is called cross-tolerance or multiple-stress resistance. Due to a rapidly changing environment, in prokaryotic microorganisms cross-tolerance to environmental stressors seems to be the common case rather than an exception and is based on one key regulatory pathway, the σS regulation (see also Chap. 7), whereas cross-tolerance is somewhat less common in eukaryotic organisms and based on several regulatory mechanisms.
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