Abstract
Gold nanoparticles (AuNPs) made from self-assembling peptides have been used in many research fields and attracted a great deal of attention due to their high stability, biocompatibility and functionality. However, existing preparation methods for peptide-coated AuNPs are post-synthesis processes, which are complicated and time consuming. Therefore, a one-step preparation method for peptide-coated AuNPs is proposed here. The AuNPs obtained by this method exhibit good stability. Importantly, peptide-coated AuNPs with precise different sizes can be prepared by this method through pH control of reducing reagent tyrosine in range of 10.0~12.7. Thus, the one-step preparation method proposed here provides a significant tool for the research in different fields concerning NP size, stability and biocompatibility.
Highlights
In recent decades, nanomaterials made from self-assembling peptides have attracted a great deal of attention from researchers because of the designability and functionality of peptides
Solution, because reducibility of thetyrosine phenol was group of tyrosine dissolving in 0.05 solution, the reducibility of the phenol of tyrosine is is related to the pHmol/L
Three different procedures described in the Materials and Methods section were investigated, varying the feeding order of described the Materials andinMethods investigated,ofvarying order reactants
Summary
Nanomaterials made from self-assembling peptides have attracted a great deal of attention from researchers because of the designability and functionality of peptides. Lots of nanomaterials with peptide-formed monolayers have been obtained, including silver [2,3], gold [4], carbon nanomaterials [5,6], magnetic nanoparticles [7,8] and silica nanoparticles [9] These materials show advantages such as high biocompatibility and high stability in various applications, for example, as chemical sensors [10], biosensors [11], in enzyme activity analysis [12,13], bio-imaging [14], drug delivery [9], diagnosis and therapy [4,6,8] and nano-architecture fabrication [15,16]. That is why many researchers have focused on the self-assembly of peptides
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