One-step and in-situ catalytic synthesis of acrylates from acetates (or propionates) and trioxane at room temperature

Abstract

Abstract One-step synthesis of acrylates from acetates and trioxane via aldol reaction at 623 K–653 K was reported. But proceeding this process at room temperature is still a challenge due to ester activation and trioxane decomposition. Herein, series of acrylates were firstly achieved, with the one-step and in-situ catalytic strategy, from acetates (or propionates) and trioxane at 293 K. Selectivity of product reaches up to 94.4% with a 80.8% yield. 1 H NMR confirmed the soft enolization of ester, the decomposition of trioxane was catalyzed by TMSOTf, and the generated ionic liquid has catalytic performance on aldol condensation step.