Abstract
AbstractA one‐pot two‐step double annulation strategy to produce isoindolo[2,1‐b]isoquinolin‐5(7H)‐ones via the reaction of N‐methoxybenzamides with symmetrical/unsymmetrical alkynes and alkenes has been developed, which proceeds through Ru‐catalysed unsymmetrical double annulations using a single DG under single catalytic conditions. Furthermore, we have developed amide‐alkyne regioselective annulations using unsymmetrical internal alkynes having oxygen/nitrogen substituents leading to a single isomer. The developed procedure offers broad substrate scope, tolerates a wide range of functional groups and affords good product yields.magnified image
Published Version
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