One-pot Synthesis of Bicarbazole-substituted Triary-methanols based on α-Keto Acids

Abstract

In this work, carbazoles, one of the most important types of nitrogenous compounds, were used as substrates to synthesize bicarbazolyl-substituted triaryl-methanols in moderate to excellent yields (up to 95%). This simple and efficient strategy can regioselectively form a sp3 quaternary carbon with two large sterically hindered carbazole rings, one benzene ring and an active hydroxyl group in a one-pot reaction. These obtained triarylmethane products are all new products, and have the high potential as building blocks for medicinal chemistry or material science.