Abstract
In this work, the synthesis, characterization and in vitro antibacterial activity of two novel compounds with aminophosphinic acid groups have been investigated. Both α-propylaminophosphinic acid grafted on styrene-6.7%divinylbenzene copolymer (AmPhinicPr) and α-benzylaminophosphinic acid grafted on styrene-6.7%divinylbenzene copolymer (AmPhinicBz) were obtained by a one-pot Kabachnik–Fields polymer-analog reaction. They were characterized using FT-IR spectroscopy, EDX and TG/DTA, to establish the degree of functionalization with pendant α-aminophosphinic acid groups. They exhibited remarkable efficiency in antibacterial tests. The bioactive aminophosphinic groups have an antibacterial effect against Staphylococcus aureus (S.aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and Bacillus cereus (B. cereus). We have evaluated the applicability of the Weibull model to describe inactivation of microbial cells at our samples.
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