Abstract
During last few decades, oligochitosan (OCS)-coated nanoparticles have received great interest for nanomedicine, food and environment applications. However, their current formulation techniques are time-consuming with multi-synthesis/purification steps and sometimes require the use of organic solvents, crosslinkers and surfactants. Herein, we report a facile and rapid one-pot synthesis of OCS-based nanoparticles using photo-initiated reversible addition fragmentation chain transfer polymerization-induced self-assembly (Photo-RAFT PISA) under UV-irradiation at room temperature. To achieve this, OCS was first functionalized by a chain transfer agent (CTA) resulting in a macromolecular chain transfer agent (OCS-CTA), which will act as a reactive electrostatic/steric stabilizer. Owing to its UV-sensitivity, OCS-CTA was then used as photo-iniferter to initiate the polymerization of 2-hydroxypropyl methacrylate (HPMA) in aqueous acidic buffer, resulting in OCS-g-PHPMA amphiphilic grafted copolymers which self-assemble into nano-objects. Transmission electron microscopy and light scattering analysis reveal formation of spherical nanostructures.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Chemphyschem : a European journal of chemical physics and physical chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
